Estrogen Metabolite Index and Breast Cancer: What We Need To Know

Apart from timely mammography for breast abnormality evaluation, a simple urine test on Estrogen Metabolite Index (EMI) can help in determining whether one is at risk for developing breast cancer.

Are you concerned whether your intake of Oral Contraceptive Pills or Hormone Replacement Therapy may put you at risk? The following bit of information may answer some of those gnawing questions.

From Estrogen Carcinogenesis in Breast Cancer by James D. Yager, Ph.D., and Nancy E. Davidson, M.D., New England Journal of Medicine [2006;354:270-82]:

Studies of breast cancer have consistently found an increased risk associated with elevated blood levels of endogenous estrogen, clinical indicators of persistently elevated blood estrogen levels, and exposure to exogenous estrogen plus progestin through hormone-replacement therapy and the use of oral contraceptives. In experimental animals, estrogen treatment leads to the development of mammary tumors. Together, these observations support the hypothesis that estrogen is a mammary-gland carcinogen.

[Full article online.]


More about this specific test from Genova Diagnostics:

A proper balance between 2-OHE1 and 16alpha-OHE1 is the key to optimal health. Measuring these primary estrogen metabolites allows practitioners to develop individualized therapy based on each woman’s unique health risks.Flaxseed (lignans), soy products (isoflavones), cruciferous vegetables (indole-3-carbinol), vigorous exercise, and omega-3 fatty acids are interventions that may reduce the risk of estrogen-dependent disease by favorably modifying the 2:16alpha-OHE1 ratio. Using this assessment, practitioners can monitor the physiological impact of these and other treatments (including hormone replacement therapy), gaining added insight into their clinical safety and effectiveness.The Estrogen Metabolism Index is designed for both premenopausal and postmenopausal women. The test is fully validated and approved for in vitro diagnostic use by the FDA. Urine testing offers convenient, noninvasive sample collection. In urine, 2-OHE1 is the primary 2-hydroxyestrogen measured, although urinary analysis also detects small amounts of other 2-hydroxyestrogens.

[Full article here.]

Related article from the Mayo Clinic Proceedings here.

Do not be overwhelmed. It is as simple as a cup of urine first thing in the morning. Ask your physician about it on your next visit. It may save you some unnecessary worries.


~ by Karina Descartin on 16 October 2007.

3 Responses to “Estrogen Metabolite Index and Breast Cancer: What We Need To Know”

  1. totally off topic but related to breasts…mam have you heard of blauffont breast pills? not sure if i had it correctly spelled but something that would sound the same might be okay haha. my friend whos got this friend uses this pill and instead of having an improved breast size, she got rashes or something…hmm. is this pill safe?

  2. Hi Karina, I am sorry to leave the link to the photo that you ask here, but I could not find your email.
    The original photo belongs to julie lindsay. It has a creative commons license.
    Follow the link to get it without letters:

    Best Regards

  3. Thanks very much for the information, Victor.
    All the best to you too.

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